Feature

LSD: Research & Joy Ride LSD: Research & Joy Ride

LSD 25 , an indole derivative from ergot, was synthesized by Hoffman in 1938, but for a good many years little attention was paid to the drug. Then, within the past year or two, interest in this psychedelic or "mind manifesting" drug has soared among both professionals and the lay public. LSD has been widely publicized in nonmedical publications, a number of sociologic studies exist, and a journal has been founded to report experiences resulting from its use. Three different approaches to LSD have been described and studied to date. The first is the experimental administration of the drug in controlled laboratory setting, a record being kept of subjective and/or objective effects. Initially the so-called "model psychoses" induced by LSD were compared with schizophrenia and with delirium. However, this method of comparative study has proved to be somewhat disappointing. The second aspect of study has been the psychotherapeutic use of LSD to increase awareness, lift repressions and facilitate insight during psychotherapy LSD is also used for treatment of specific disorders such as alcoholism. The third type of study, and the one which concerns us most, has to do with the psychiatric side effects that follow ingestion of LSD. Most of this study is concerned with self-administered doses of the drug. The side effects occur regardless of the sources of the drug and regardless of the setting in which it has been administered, but far more LSD is bought on the black market (it is either imported illegally from Mexico or produced locally by amateur chemists) than is given experimentally or psychotherapeutically. LSD obtained on the street often contains a number of impurities; sometimes other compounds (among them atropine) are sold allegedly as LSD. Black market doses, usually diluted as they are passed on, contain an unknown number of micrograms of LSD. Psychiatrists throughout the country have been observing increasing numbers of severe side effects from the drug over the past seven or eight months. (An excellent early personal account of a "bad trip" from LSD was "They Split My Personality" by Harry Asher, Saturday Review, June 1, 1963.) At the UCLA Medical Center, approximately one psychiatric disorder associated with LSD ingestion had been turning up every other month. However, beginning in September of 1965, the figure jumped to between five and fifteen cases a month. Other local facilities in the Los Angeles area have reported a similar increase. The new Federal Drug Abuse Control Amendments of 1965, which went into effect on February 1, have had no apparent effect in decreasing the number of LSD cases seen in our psychiatric emergency room. About one-third of the LSD cases at UCLA have required admission to the psychiatric hospital; approximately half of these to the ward on which the authors work. In addition, we have conducted group therapy sessions once a week for several months among all the hospitalized LSD patients whose doctors would permit them to attend. The purpose was to learn what reactions these patients had experienced and to become acquainted with the patients themselves. The LSD users who come to the hospital are primarily young, single, Caucasian, male; few are religious. They live throughout the Los Angeles area, but particularly in the Hollywood section and the beach cities. Most of them are unemployed, but some are students. Many of our patients had used other drugs besides LSD, particularly marijuana; some had taken LSD as often as sixty times. These people came to the emergency room suffering from confusion, anxiety, depression, suspiciousness and hallucinations. During this study we became curious about the overall LSD population. Were we seeing atypical reactions or were others reacting the same way to LSD but not being brought into the hospital? As word spread of our interest, informants began to appear at the hospital. They told us of other LSD users in the community and of their aberrant behavior. We heard about people wandering about in chronic states of confusion, and the psychiatrists on duty at the hospital received many phone calls about threatened or already attempted suicides and other disturbed behavior. Many of these people refused to come in to the hospital. We then began to go out into the community and attended a number of LSD sessions held in private homes or "pads." We observed what we would consider obvious psychotlc behavior: suspiciousness, grimacing, inappropriate affect, apparent hallucinations and motor restlessness. These affects seemed eventually to wear off and the patients we saw did not apparently harm themselves that day. We heard about others who had had unpleasant symptoms or utterly lost contact, and then recovered only to have these symptoms return weeks or months later without their having taken LSD again. Besides these acute difficulties, there are other, more chronic problems. For one thing, LSD seems to affect a person's value system. We have found that in many instances formerly productive individuals have adopted the attitude that one should live merely for subjective experiences, and not play the various "games"—like work—that society demands. We have met this attitude in musicians, lawyers, psychologists and doctors. Since many people who experience this change of attitude are never seen by psychiatrists, one can only speculate as to its frequency. Another chronic difficulty is perceptual distortion. For example, a band leader phoned us because his players were producing such terrible music. Nor could he talk to them, for they were on LSD and utterly convinced that the band was playing the most beautiful music ever heard. A law student told us that LSD had given him such new insight and opened such horizons that he felt his legal studies were dull and boring by comparison. He speculated at length about the advisability of giving the world's leaders LSD so that they would love and not hate. At last contact he had not decided whether to pursue his law studies or to continue with LSD full time. We have observed this degree of subjective distortion among many LSD users. A group of them whom we studied fairly intensively over several months were convinced that they could "pick up vibrations" from other people, that they could tell if someone else had used LSD by casual inspection, that they had a keen awareness of music and art. Nevertheless, objective tests showed that their ability to discriminate was below normal, and that their powers of observation had been actually decreased by LSD. At various community dances which we attended, the young girls were in their "psychedelic slacks" and the teenage boys wore long hair and sunglasses. They moved beneath undulating lights in bright "psychedelic" colors. At such gatherings the drug seemed to replace personal contact and to substitute for the drives of sex and aggression. We watched seven or eight sailors dancing with one girl on the floor. There was little male-female awareness or physical contact; each was in his own fantasy world. The criteria for mental health, according to Freud, are the ability to work and to love, and LSD users seem to deteriorate in those very areas. We have already mentioned the numerous individuals we have studied who have either lost their jobs or lost the incentive to work after using LSD. The ability to love, that is to have psychic intimacy with another person, seems also to be decreased by LSD. In contradiction to the claim that the drug helps one to get closer to people, we note that users become more introspective and invested in themselves. The extreme results are autism and psychosis. Advocates of LSD have maintained that proper screening techniques would enable one to predict individual reactions to LSD and to eliminate those who would have "bad trips." Our experience at UCLA indicates that such predictions are extremely unreliable. We know of patients who, though carefully screened for research purposes, suffered severe LSD reactions, with dramatic alterations of their value systems, resulting in a diminished level of functioning. On the other hand, we have come across members of the community whom we would have judged fairly unstable but who showed little or no change after using LSD. The number of high school students and teen-agers who take the drug is increasing rapidly. Most adolescents are struggling with feelings of aggression and sexuality, along with their need to establish an identity. LSD can seem a "magic" solution to such problems. It offers a ready-made identity with fellow users and the introspective experience helps to deny the feelings of both aggression and sexuality. Their conversation becomes "acid head" talk. Bad "trips" are "freak." Every stranger is "the man" (police) and to talk to one would be to "cop-out" (squeal). Suspicion to the point of paranoia is common. The adolescent is frequently overwhelmed by the LSD experience, with the result that the search for identity becomes a florid psychotic nightmare. There is perhaps no period of life more loaded with conflict, and one might therefore expect that adolescents who took LSD would experience severe complications, including panic states, prolonged psychosis and severe depressions. Another disturbing aspect of LSD usage is the missionary zeal it seems to induce in many of its users. We have no doubt that the enthusiasm is sincere, since we have come upon cases of mothers who have given LSD to their children, brothers who have encouraged their sisters to take it, and many individuals who have selected their closest friends and used every means possible to convince them that they too should share in the world of psychedelia. In several instances, individuals have devoted a great deal of their energies to buying LSD and passing it out free among the population in an attempt to "save the world." The right environment for taking LSD (often alluded to by acid heads as necessary for a good trip) means having a "sitter" to guide you through the LSD state. However, neither a favorable environment nor a guide guarantees a pleasant or meaningful experience. If the trip goes bad, and LSD users are brought to a medical facility in the acute phase, tranquilizers and barbiturates will help most of them, but not all. Many of our hospitalized patients have remained in the hospital for more than a month. Until more is known about LSD and its short- and long-term effects, it must be considered a very dangerous drug. Unfortunately, the ready market for and easy manufacture of the drug have resulted in an almost unlimited black market supply, and the buyers are often the very people who have the most to lose from its use. We certainly hope that LSD research will be continued,. but we appeal to those who loudly proclaim that "everyone" should take LSD to remember the highly subjective response to the drug. We have known the most ardent enthusiasts to become the most eloquent opponents—often after just one bad experience. The controversy continues to rage, some investigators maintaining that side effects are frequent, others stating that the potential gains far outweigh possible side effects. We are worried by what we have seen. California and other states are now considering legislation to supplement existing federal legislation; Sandoz Laboratories, the principal legitimate source, has discontinued manufacture. The future of LSD remalns controversial and uncertain.

Dec 8, 2010 / Feature / Dr. J. Thomas Ungerleider and Dr. Duke D. Fisher

Drugs on Campus: Turned On & Tuned Out Drugs on Campus: Turned On & Tuned Out

Within the last five years the ingestion of various drugs has become widespread on the American campus. Until recently, drugs were used almost exclusively by those clearly out of step with conventional American life Prior to 1960, also, the taking of drugs implied physiological addiction, heroin being the substance most used. An exception was marijuana. Certain groups in Los Angeles and New York, many of them actors and writers, smoked pot without deleterious physiological effects or interference with their professional activities. However, marijuana was very rarely found on college campuses Physiologically addictive drugs are still almost unknown on campus, but there are now few colleges and universities where marijuana and the new psychedelic drugs, chiefly LSD, are not consumed. On even the most provincial of campuses a student who has flipped out as a result of taking LSD is likely to turn up at the counseling center, or a few students may be expelled for smoking pot in a dormitory. This is not to say that the proportion of students who take drugs is high. Most college students are conventional and dutiful, and are unlikely to contravene acceptable standards of behavior in so serious a way. But on campuses where cosmopolitan students congregate—large city campuses or prestigious small liberal arts colleges—the proportion of students who experiment with pot or LSD may run as high as 10 per cent. This is not a large proportion, but the total numbers are considerable. In a student body of 15,000, for example, but 2 per cent is 300 students—a figure not easily ignored. And the number of drug takers is growing. It is difficult to fashion a serious case against smoking marijuana except that a user will find himself in serious trouble if he is caught by the police. The effects on society at large, were pot smoking to be as ubiquitous as the consumption of alcohol, are unknown, but within the current limits of use, there is little evidence that marijuana damages the individuals who smoke it. However, once a student has stepped over the line and finds that nothing terrible has happened, it is easy to fall into the illusion that there are no dangers at all. Occasionally a person of somewhat precarious emotional stability may be thrown into a panic state or even a psychosis as a result of smoking pot, but this seldom happens. Similarly, there is little basis for asserting that pot smoking is often a prelude to self-destructive or socially damaging acts. No data exist, for example, to demonstrate that marijuana contributes significantly to an individual’s criminal tendencies. Perhaps the most serious charge that may be made against pot is that it is psychologically damaging. Since it is officially banned, its use reinforces rebellious and anti-social tendencies. Individuals who smoke pot regularly—as opposed to those who experiment with it on one or a few occasions—are likely to scoff at such a remark. Divorced as they are from traditional American culture and society, they are hardly frightened by the prospect of further alienation. Indeed, they are apt to welcome it. The consistent pot smokers are for the most part graduate students in the arts, philosophy, the humanities and, to some extent, in the social sciences. The rebellion they express in many ways, pot smoking among them, stems from their disillusion with American life and values. They oppose American intervention in Vietnam, they are angered by the lot of Negroes and other disadvantaged minority groups. And they are militant. Aside from enjoying pot’s intrinsic satisfactions—relaxation, heightened sensibility, etc.—these students get pleasure from sharing a rebellious, illegal activity. The more rebellious or "anti" the movement, the greater the likelihood that pot smokers will be drawn to it. On the other hand, the use of marijuana is rare in the Peace Corps and Poverty Corps. Even though these workers may oppose traditional policies and politics, their activities are more a gesture of social affirmation than of protest. On any cosmopolitan campus today or in any large city, a student can easily buy marijuana or a psychedelic drug. About eighty psychedelic or consciousness-expanding substances have been identified in the Western world—morning glory seeds, peyote, psilocybin, are among the more prominent—but LSD, the most powerful, has preempted the field. Because of its shadowy status, it has often been easier to obtain than the clearly illegal marijuana. Revisions of federal drug laws will alter the status of LSD, but at least in the near future there is little likelihood that pot or acid will be in short supply. Connections, sometimes students, often ex-students, are easy to find. The going rate is $5 for an LSD capsule. And for many users one capsule is good for two "trips." You dissolve it in a glass of water and drink half the glass each time. Although the takers of marijuana and LSD overlap, these drugs have assumed quite different meanings for the students who ingest them. Pot smoking is likely to be a relaxing, convivial affair. On occasion, one may in the course of smoking marijuana undergo profound experiences, mystical or self-revelatory, but few pot enthusiasts would claim that it initiated one into life’s mysteries. Devotees of LSD, on the other hand, have surrounded the ingestion of this substance with a mystique, with cults, with rituals. Some students claim that LSD experiences provide deep insights. They have seen themselves with a clear eye, stripped of the usual defenses and artifices which ordinarily hedge perception. A better self, an ideal self, may be envisioned. New powers are made available to them, intense mystical or religious experiences occur. However, not all ingestions of LSD result in revelatory trips. Sometimes nothing happens. Other times, reaction may be limited to minor perceptual distortion. The setting in which LSD is taken considerably influences the effect. For some students an LSD trip is a profound personal experience; for others it becomes a religion, a way of life. These two kinds of LSD enthusiasm —the profound personal experience versus the way of life—tend to divide on the frequency of dosage. Students for whom LSD has not become a way of life probably have experienced only a few LSD trips—three or four perhaps, spaced at intervals of several months. LSD experience is likely to contribute to their alienation. They see so very clearly the falsity of the material values that dominate Western society, they have experienced true love—they know what the word love means; they have reconciled the conflicts which plague Western man, and so on. And these experiences have spurred them on to rebel all the more vehemently against conventional American life and politics. When LSD becomes a religion or a way of life, students take it more frequently—once a week perhaps, or even more often. And when this occurs, a student is likely to leave school. A number of large universities now have groups or cults of LSD devotees who live in the vicinity. Most of the members are ex-students. These people are turned on to their inner world, their internal experience. The external world is tuned out. They do little of anything except observe. They are great nature lovers. They will journey to places of unusual natural beauty, turn on with LSD, and look. They work spasmodically, when funds are needed, but otherwise are inactive. The preoccupations of most people—educational, professional, political—are "games" to them. There is the "Vietnam-administration game," the "student-administration game," the "Hitler- Jewish game," the "McCarthy-ADA game," and the like. Their living conditions often become squalid. The truth has been revealed to them. They are in tune with infinity, and anyone who is hung up on involvement with experiences or activities of the external world is dismissed as a square. Communication between these votaries of LSD and squares is limited. Because so much of what occurs during an LSD trip is nonverbal, little can be reported. And "what the word cannot say, the mind cannot know." LSD enthusiasts talk of religious conversions, the awakening of artistic creativity, the reconciliation of opposites. The main change to be observed in such individuals, however, is that they have given up doing anything. The aspiring painter talks of the heightening of his aesthetic sensibilities and skills, but he has stopped painting. The graduate student who withdrew from writing his dissertation in philosophy talks of the wondrous philosophical theories he evolved. But nothing is written. It seems that the world of fantasy has become far more compelling than the world of involvement with external things. Indeed, fantasy is substituted for reality. If one has dreamed the idea of a great novel, the work of actually writing it becomes a drag. Much has been made of the psychological perils of LSD. They are real enough. In San Francisco or New York one could doubtless track down a hundred or more cases of people who had been rendered psychotic as a result of a dose ot LSD. Each student health service, psychiatric clinic, emergency service of a general hospital, would yield a number of such cases. Most of these episodes are of short duration. For each instance of an individual’s flipping out, there are several of panic reaction to an LSD experience. Tranquilizers will terminate the physiological effects of LSD in such instances. Most of these reactions occur when LSD is taken in unfavorable settings—alone in a room or in somewhat uncongenial company. Probably more serious is the impairment of judgment that may accompany an LSD trip. It is often difficult to determine the duration of the experience. Individuals whose customary judgment is still somewhat impaired may be driving cars, teaching classes, or making decisions about important family matters. The long-range physiological results of such a powerful stress reaction as an LSD experience are unknown. Evidence seems to be mounting that repeated ingestions of LSD may have permanent or enduring adverse effects. The semi-dazed quality displayed by some individuals who are on LSD a good part of the time may be physiological in origin, at least in part. It is unlikely that one or several ingestions of LSD will have enduring physiological effects, but definitive data on this score are not yet at hand. It is in quietism, however, that the chief danger of LSD lies. An affluent and complex society can easily afford small groups of people whose chief commitment is to their internal processes and their fantasy worlds. But what if there were many such? It is ironic that the military establishments of both Russia and the United Stales, the very groups that epitomize all the devotees of consciousness expansion most oppose, are experimenting with LSD—as a weapon, of course. A population that is turned on will make no trouble. It will be easy prey for the conqueror. LSD zealots ignore the realities of power—unlike Mahatma Gandhi or William Blake, mystics who were committed to the human and social struggle. LSD is unquestionably of potential value in various forms of psychotherapy. It may be used, for example, to shatter the habitual modes of reaction of people with strong fixations—alcoholics, recidivist criminals, compulsives, and others—so that they may evolve new ways of coping with the world and of living with themselves. And undoubtedly psychedelic experiences have entailed for some people profound personal insights and mystical and spiritual experiences. These powers are to be taken seriously. It is more difficult to take LSD seriously as a religion or a way of life. The notion that in 3 to 6 hours one may painlessly attain to the wisdom that Buddha achieved over a period of years seems ludicrous. The LSD grab bag of philosophy compounded out of Zen, Fromm , existentialism, Aldous Huxley, Jung, et al., is an unlikely guide to action in a complex society. The description of a person as "He's loving" (the ultimate compliment), as if somehow one could touch this entity of love, is right out of adolescent fantasy. Above all, the absence of a tragic sense makes LSD as a religion or way of life no more applicable to the richness of human experience than any other simplistic religion. Yet the phenomenon of psychedelic experience as a religion or way of life should not be written off. What attracts several hundreds of the brightest and most aware of American youth to psychedelic experience and makes zealots of them? Why are many thousands of other youths eager to undergo this experience? The answers are, of course, many and varied. Transcendentalism and the search for utopia are hardly new to American life. There is, however, an urgency to the quest by many young people for new values that deserves the most serious regard. The brightest and most sensitive of college youth are examining the values of the Western world, and are finding them wanting. There is an upsurge of interest in introspection and in the life of the emotions. There is great concern with people rather than with things. Questions of ethics and morality are on their minds as perhaps never before in American life—not since the Civil War, at any rate. And their education is not meeting these interests. The things that are most important to many young Americans are not being discussed in academic life. The sterile formalism of much American higher education can hardly hold a candle to the psychedelic experience. Similarly, many youths are turning away in disgust from American society. Injustices that were once accepted lightly—the situation of the Negro, for example—are now a source of pain. A war in Vietnam of most ambiguous morality cannot be easily tolerated. A society which expends enormous wealth on orbiting space ships, the occupants of which can talk to each other only by recourse to locker-room banter, seems almost unendurable. The interest of many students in drug experience may not be dismissed simply as a sign of delinquency, rebelliousness or psychological pathology. It represents a search for a new way of life. It indicates needs and desires that American society and education do not now meet or fill. There is a quality of naïveté in this quest by students. Wholeness, joy, wisdom or love are not likely to emerge from a few hours that are spent under the influence of a chemical. The interest in drug experience informs us, however, that American society and education are doing little to contribute to the richness of life that students sense can be theirs.

Dec 8, 2010 / Feature / Mervin B. Freedman and Harvey Powelson

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